The first metaplot storyline for Shadowrun, Fifth Edition involved Cognitive Fragmentation Disorder, a condition caused by nanites that infect the brain and overwrite the victim's personality.
Stolen Souls (200pp, retail price $25): Across the Sixth World, people's minds are in schism, as new personalities emerge and battle the old. The world is in chaos, and there is a dramatically increased demand for extractions, to get infected people out of sensitive positions and to steal the insights of people who might know what's gone wrong. Stolen Souls is a Deep Shadows sourcebook with plot updates and adventure hooks, as well as information, techniques, and gear to help make runners extraction aces. It also contains setting information about Manhattan, where key extractions are taking place.
Lockdown (240pp, retail $25): Panic is spreading through the northeastern sprawl, and Boston-based NeoNET is at the center of the storm. Lockdown is a plot sourcebook with mission hooks, setting details of Boston, character details, and surprising reveals.
Dark Terrors (184pp, retail $20): Dark Terrors is a catalog of the horrors lurking under the Sixth World. Bug spirits work to devour corporations from within. Shedim claim dead bodies and mobilize to their own dark ends. And the hidden corners of the metaplanes and the Matrix contain creatures best not imagined. [Previously in SR5 Runs and Guns, Feb 2019.]
Bloody Business (160pp, retail $25): Many of the megacorps are currently reeling, hit by multiple harsh wallops. NeoNET and Evo are dealing with the fallout of the CFD virus, Ares has powerful forces eating it from inside, Horizon backed the losing side of the Aztlan-Amazonia war, and the Japanacorps are rearing back to take on the world and each other. When the corps get aggressive, shadowrunners get called, and blood gets shed.
Market Panic (208pp, retail $25): The Big Ten megacorporations of the Sixth World are reeling, with scandals, disasters, and crippling attacks from all angles. Every corp is a pile of schemes, turmoil, upheaval, and teetering chaos, because that's how they operate. Market Panic runs down the state of the Big Ten post-CFD, providing background, story developments, and plot hook.
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